Search on: CCN INTERCELLULAR SIGNALING PROTEINS 
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Descriptor English:   CCN Intercellular Signaling Proteins 
Descriptor Spanish:   proteínas CCN de señalización intercelular 
Descriptor Portuguese:   Proteínas de Sinalização Intercelular CCN 
Synonyms English:   CCN Family Proteins
CYR61 CTGF NOV Matricellular Proteins
Matricellular CCN Proteins  
Tree Number:   D12.644.276.200
D12.776.467.200
D12.776.860.300.200
D23.529.237
Definition English:   A family of secreted proteins found associated with the EXTRACELLULAR MATRIX and cell surface receptors. They are believed to play a role in modulating the effects of a variety of GROWTH FACTORS and PROTEASES at the cell membrane extracellular matrix. The CCN protein family is named after three protypical members; CYSTEINE-RICH PROTEIN 61; CONNECTIVE TISSUE GROWTH FACTOR; and NEPHROBLASTOMA OVEREXPRESSED PROTEIN. 
History Note English:   2009 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AG agonists AN analysis
AI antagonists & inhibitors BI biosynthesis
BL blood CF cerebrospinal fluid
CS chemical synthesis CH chemistry
CL classification DF deficiency
DE drug effects EC economics
GE genetics HI history
IM immunology IP isolation & purification
ME metabolism PK pharmacokinetics
PD pharmacology PH physiology
PO poisoning RE radiation effects
ST standards SD supply & distribution
TU therapeutic use TO toxicity
UL ultrastructure UR urine
Record Number:   53123 
Unique Identifier:   D055511 

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